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KMID : 0854720100300030195
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 3 p.195 ~ p.201
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Association between Atopic Parameters and Thyrotropin-Binding Inhibitory Immunoglobulin in Graves` Disease
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Kim Hyo-Jeong
Lee Byoung-Hoon
Lee Jae-Hyung
Jeon Jae-Seok
Kim Sang-Hoon
Ahn Young-Min
Chae Jung-Don
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Abstract
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Background: IgE might play a role in the pathogenesis of Graves’ disease in Japanese population.
Objective: We designed this study to evaluate the possible relationship between atopic parameters and the level of TSH receptor antibody in Graves’ disease.
Method: In 406 patients with Graves’ disease, we measured total IgE, eosinophil count and specific IgE against Dermatophagoides farinae (D. farinae), as well as TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin [TBII]). We collected histories of common allergic diseases by a questionnaire and performed skin tests with 8 common aeroallergens.
Result: TBII was higher in patients who had treatment history or clinical symptoms of asthma within 12 months
and also higher in smokers. TBII was positively related to total IgE. Duration of treatment was significantly lower and
total IgE was significantly higher in TBII ≥15 IU/L group than those of TBII ＜15 IU/L group. TBII was significantly higher in group of specific IgE against D. farinae ≥0.7 kU/L. Total IgE level was higher in whom need medication for maintaining euthyroid state than that of remission state patients.
Conclusion: TBII was significantly related to atopic markers including total IgE, specific IgE against D. farinae and
history of asthma, suggesting that there is a close link between autoimmune thyroid disease and allergic immune
response.
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KEYWORD
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Graves` disease, Atopy, Immunoglobulin E, Thyrotropin-binding inhibiting immunoglobulin, Smoking
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